Other diseases2018-11-20T14:00:18+00:00

Exemples of achievements

OTHER DISEASES

Description

Species : mouse

Sample : liver

Staining : Rhodamine

Case study summary

Quantification of copper deposits in the liver enabling the evaluation of the efficacy of a therapeutic molecule in Wilson’s disease.

Description

Species : mouse

Sample : liver

Labeling : Cleaved Caspase-3

 

Case study summary

Evaluation of apoptosis by histopathological reading on the slides immunolabelled against cleaved caspase-3.

 

Description

Species : mouse

Sample : brain

Labeling : β-Amyloid

 

Case study summary

Detection of amyloid plaques formation on an Alzheimer mouse model by anti-β-amyloid immunostaining.

 

Other diseases : Wilson’s disease, quantification of copper deposition in the liver

WILSON’s disease is a genetic disorder which is characterized by a toxic accumulation of copper in the organism. The lesions are essentially localized in the liver and the brain.

In this video, we present a technique for the analysis of images, developed internally by HISTALIM, making it possible to highlight and quantify the copper deposits in a mouse liver (pathological model). This tool may be applied in toxicology, preclinical development and more specifically in the context of WILSON’s disease.